Ketamine Selected Literature References

Below are some selected references related to off-label ketamine applications for:

    • Depression
    • Obsessive Compulsive Disorder and Anxiety Disorders
    • Post-Traumatic Stress Disorder (PTSD)
    • Chronic pain syndromes
    • Tinnitus
    • Traumatic Brain Injury Recovery
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Ketamine for Depression

Grady SE, Marsh TA, Tenhouse A, Klein K. Ketamine for the treatment of major depressive disorder and bipolar depression: A review of the literature. Ment Health Clin. 2017 Jan;7(1) 16-23.

Vollenweider, F. X., & Kometer, M. (2010). The neurobiology of psychedelic drugs: implications for the treatment of mood disorders. Nat Rev Neurosci, 11(9), 642-651.

Serafini, G. et al. NMDA receptor antagonists for depression: Critical considerations. Ann Clin Psychiatry (2015), 27(3), 213-220.

Serafini G, Howland RH, Rovedi F, Girardi P, Amore M. The role of ketamine in treatment-resistant depression: a systematic review. Curr Neuropharmacol. 2014;12(5):444-61.

Murrough, J. et al. Ketamine for rapid reduction of suicidal ideation: A randomized controlled trial. Psychological Medicine (2015), 45(16), 3571-3580.

Ketamine for Obsessive-Compulsive Disorder (OCD)

Rodriguez CI, Kegeles LS, Levinson A, et al. Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: proof-of-concept. Neuropsychopharmacology. 2013;38(12):2475-83.

Glutamate modulators in the treatment of obsessive-compulsive disorder. Psychiatr Ann. 2015;45(6):308-315.

Ketamine for Post-Traumatic Stress Disorder (PTSD)

Albott CS et al. Efficacy, Safety, and Durability of Repeated Ketamine Infusions for Comorbid Posttraumatic Stress Disorder and Treatment-Resistant Depression. J Clin Psychiatry. 2018 May/Jun;79(3).

Feder A et al. Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder, A Randomized Clinical Trial. JAMA Psychiatry. 2014;71(6):681–688.

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