Bone Broth: #Paleo Goodness or Lead Toxicity Risk?

The consumption of bone marrow and bone broths have become more commonplace, and even hip, with the rise in popularity of the Paleo Diet, Perfect Health Diet and GAPS Diet. Bone broths are meant to be a staple in evolutionary-type diets as a rich source of calcium and other minerals. It is made by submerging bones and any other uneaten part of the animal in water, and simmering for 12 to 48 hours. This process allows the minerals to dissolve into the water as the bones and cartilage disintegrate. Bone broth is thus rich in calcium, phosphorous, magnesium, collagen (which is made of protein, specifically the amino acids proline and glycine), glucosamine, chondroitin, keratin and hyaluronic acid.

These constituents are nuritionally useful for many of the body’s physiological processes, including:

Broth

Bone Broth

  • Bone growth and repair (especially if you stress fractured your feet wearing barefoot runners)
  • Glucose production and blood detoxification by the liver
  • Tissue healing and maintenance
  • Plasma production
  • Digestion and absorption of nutrients
  • Muscle contraction
  • Thyroid function.

Sounds great, right? Bone broths are certainly a powerful food and quite important when dairy is not being consumed. However, a study was recently published in the journal Medical Hypotheses (http://www NULL.medical-hypotheses NULL.com/article/S0306-9877(13)00013-3/abstract) raising concerns of lead contamination in commercially-available bone broths. Lead toxicity in humans can cause reproductive and gastrointestinal problems, neuropathy, anemia, abdominal pain, memory impairment, and depression, and recent studies suggest that even small amounts of lead exposure can cause trouble.

Lead is stored in bones and thus it was hypothesized that the lead concentration in bone broths would greatly exceed that of tap water. The researchers investigated three different broths made with tap water and organic chicken bones, meat without the bones, and skin and cartilage without the bones. The tap water used to make the broths had 89 parts per billion of lead. The bone broth contained 700 parts per billion and the skin and cartilage broth contained 950 parts per billion. This may sound alarming at first, but keep in mind that the legal limit for lead in drinking water is actually 1500 parts per billion. It is possible that the benefits of bone broths surpass the increased exposure to lead, but this is likely both dosage dependent and individual. It’s also unclear whether pasture-raised animals, preferred in the Paleo Diet, might have less lead in their bones than standard grain-fed animals (organic or not).  Certain individuals and populations, like pregnant women, should take greater care to avoid lead exposure.

If you frequently consume bone broths, one prudent measure would be to have your doctor order a blood test for lead and possibly erythrocyte protoporphryn (EP), which will see if your recent bone broth ingestion pattern has resulted in significant lead exposure.

Link to Study in Medical Hypotheses (http://www NULL.medical-hypotheses NULL.com/article/S0306-9877(13)00013-3/abstract)

 

Be Fruitful Book

Review: “Be Fruitful” book on fertiliity by Victoria Maizes MD

Book Review: “Be Fruitful: The Essential Guide to Maximizing Fertility and Giving Birth to a Healthy Child,” by Victoria Maizes MD of the Arizona Center for Integrative Medicine.

Many challenges face parents wishing to successfully conceive and give birth to a healthy child today. Drawing on her expertise in integrative medicine, Dr. Victoria Maizes integrates science with traditional wisdom to help parents-to-be to navigate the process of procreation more artfully.

Be Fruitful Book

Although this book speaks to all fertile women within the fertility range, it is most timely for young women who are possibly considering motherhood in the future. The time to prepare for healthy conception is years before you actually decide to have a child, and Dr. Maizes presents many resources to help improve the odds of a successful and healthy outcome. In addition to nicely reviewing conventional medical approaches, Dr. Maizes traverses reputable techniques and traditions ranging from nutrition, environmental health, spirituality and mind-body medicine to supplements, herbs and Traditional Chinese Medicine, giving the reader a wealth of options to choose from. Parents and “potential parents” will find the extensive additional resource list at the end of the book especially helpful.

I look forward to recommending this book to patients of mine who are considering conception, those who haven’t yet started thinking about it, and parents of young women. Dr. Maizes’ web site is here (http://victoriamaizesmd NULL.com).

 

Coronavirus

Updated: Novel respiratory coronavirus identified in travelers to Middle Eastern countries #travelmedicine

Public Health Agency of Canada: February 15, 2013
US Centers for Disease Control: March 7, 2013

Update: A total of 14 confirmed cases of novel coronavirus infection have been identified, with 8 deaths. There seems to be an association with recent travel to the Arabian Peninsula (Saudi Arabia, Qatar, Jordan) and influenza A (H1N1) co-infection. Patients presented with lower respiratory infections. Cases have been reported in the UK but not the US. Testing of specimens in the US is being done by the CDC via local health departments.

Q: How many people have been infected?
A: From April 2012 to March 2013, a total of 14 people from Jordan, Saudi Arabia, Qatar, and the United Kingdom were confirmed to have an infection caused by the novel coronavirus.

  • Saudi Arabia: 7 people; 5 of them died
  • Qatar: 2 people; both survived
  • Jordan: 2 people; both died
  • UK: 3 people; 1 died, 1 receiving treatment, 1 recovered

Original Post: In fall 2012, a novel (new) coronavirus was identified in a small number of cases of persons who went to or came from Saudi Arabia, Qatar and Jordan. A new case has recently been identified in the United Kingdom. This individual had no prior travel history, but is a relative of one of the earlier cases and has an underlying medical condition, increasing the risk for respiratory infections. This suggests that the recently identified person may have acquired the infection through human-to-human contact with the relative; however, the risk of contracting this infection is still considered to be very low.

Coronavirus

Coronaviruses  are the cause of the common cold but can also be the cause of more severe  illnesses including Severe Acute Respiratory Syndrome (SARS). At this time,  there is still more to learn about this novel coronavirus. All cases have experienced influenza-like illness including signs and symptoms of pneumonia which may include coughing, mucous, shortness of breath, malaise, chest pain and/or fever.

The World Health Organization continues to work with relevant  ministries of health and other international partners to support investigations  to gain a better understanding of the disease and its risks. There continues to be no travel restrictions as the risk to travellers remains very low.

Reference: CDC MMWR early release March 7, 2013 (http://www NULL.cdc NULL.gov/mmwr/preview/mmwrhtml/mm62e0307a1 NULL.htm).

Recommendations

Consult a travel health clinic at least six weeks before you travel.

Protect yourself and others from the spread of germs and influenza-like illness

If you are sick with influenza-like symptoms , delay travel or stay home:

  • Travelers should recognize signs and symptoms  of influenza-like illness, and delay travel or stay home if not feeling well.
  • Travelers should note that they may be subject to quarantine measures in some countries if showing flu-like symptoms.

Wash your hands frequently:

  • Avoid touching your eyes, nose and mouth with your hands as germs can be spread this way.  For example, if you touch a doorknob that has germs on it then touch your mouth, you can get sick.
  • By washing your hands with soap under warm running water for at least 20 seconds, you will reduce your chance of getting sick.
  • Use alcohol-based hand sanitizer if soap and water are not readily available. It’s a good idea to keep some with you in your pocket or purse when you travel.

Practise proper cough and sneeze etiquette:

  • Cover your mouth and nose with your arm to reduce the spread of germs. Remember if you use a tissue, dispose of it as soon as possible and wash your hands afterward
  • Try to avoid close contact with people who are sick.

Stay up-to-date with your vaccinations

There is no vaccine for this novel coronavirus, however, it is important to be up-to-date on all of your routine and recommended vaccinations, including this year’s seasonal flu vaccine, prior to travel.

Monitor your health   

If you develop symptoms that cause difficulty breathing upon your return from travel:

  • Seek medical attention immediately.
  • Tell your health care provider which countries you have visited while traveling.
Data from Article

How much will a sprained ankle cost me in the ER? Somewhere between $4 and $24110. #costsofcare

You sprain your ankle badly, and aren’t sure if it’s broken or not. It’s 6pm on a Friday evening, so you head to the ER to have it x-rayed. At triage you ask “how much might this cost me?” Typically, nobody working in the hospital at that moment will be able to even take a guess.

A new study out of UCSF (http://www NULL.plosone NULL.org/article/info%3Adoi%2F10 NULL.1371%2Fjournal NULL.pone NULL.0055491#s3), to be published in the upcoming issue of the open-source jornal PLoS ONE, looked at the bills for over 8000 emergency department visits for the ten most common ER diagnoses for patients between 18 and 64

Data from Article

years of age. The results, while not surprising to me, highlight how much financial risk you take walking into a hospital in the United States.

The prices for common conditions ranged widely. While this might reflect severity of illness and necessary diagnostics, the range of prices far exceeds the range of potential complexity:

  • Sprains and strains:  $4 to $24,110.
  • Headache: $15 to $17,797.
  • Kidney stone, $128 to $39,408.
  • Urinary tract infection? $50 to $73.002.

These are “charge master” charges (list prices), the prices that cash-paying patients are asked to pay, and that for the basis of discounts given to insurance companies. These results are consistent with the recent treatise in Time magazine by Stephen Brill on billing practices in the insurance industry (a must-read article).

Link to source article in PLOS One (http://www NULL.plosone NULL.org/article/info%3Adoi%2F10 NULL.1371%2Fjournal NULL.pone NULL.0055491#s3)

What can we do given the unpredictability of prices at most hospitals?

  1. Cultivate a relationship with a medical doctor who can help you navigate the hospital in the unlikely event that you need to use one.
  2. Have a doctor who is available enough to take care of things that don’t require a hospital, outside of the hospital, in a timely fashion.
  3. Have some kind of catastrophic insurance that will keep you from bankruptcy in the event of a sprained ankle. A policy without a low maximum payout amount.

Here in San Francisco you can always choose My Doctor Medical Group as your medical home and advocate, to help avoid some of the avoidable uncertainty and lack of transparency in the larger health care system.

Stephen Brill

Bitter Pill: Why Medical Bills are Crushing Us. Investigative reporting at its best from Stephen Brill. #costsofcare

Required reading for everyone who lives in the United States, or who is thinking about doing so: Stephen Brill delivered an amazing piece of investigative journalism last week on the U.S. health care system in Time Magazine. Hopefully everyone will read it before they develop a serious illness, but regardless it lays bare some of the reasons why the health care economy makes absolutely no sense. That in itself wouldn’t be a problem, but it’s also bankrupting individuals and the entire country, which is really a shame.

If you have ever consumed health care at a hospital and looked at the bills that resulted, you will instantly relate to his 36-page analysis of six hospital bills. But he documents in no uncertain terms the sheer brazenness of a health industry that sets prices arbitrarily, applies them unevenly, and often collects on ridiculous charges unmercifully.

I am hoping that this piece sets into motion a sea change where Americans demand in the health care economy basic things that are required in every other economy. But in a market where

Stephen Brill

Stephen Brill on the Daily Show with Jon Stewart

the consumers (people with sudden severe illness) are really not free to shop around, I think hospitals should be held to a standard of transparency and ethics that are higher than, for example, the grocery store industry.

The article is here: Bitter Pill Why Medical Bills are Crushing Us, in Time Magazine (http://ti NULL.me/15E0oam).

YouTube: Video from Time Magazine on his article (http://www NULL.youtube NULL.com/watch?v=I4yIlbh0CwE).

And watch the Entire Interview by Jon Stewart on the Daily Show (http://www NULL.thedailyshow NULL.com/watch/thu-february-21-2013/steven-brill).

Brill’s conclusion that we should simply expand Medicare to fix this problem is probably wrong. But he exposes some very fundamental flaws that every consumer should be aware of before they head to any hospital for anything, inpatient, outpatient, lab, imaging, surgical, or emergency.

He talks about billing advocates that helped people cut their bills after the fact. But it’s also critical to have a doctor who’s aware of the cost issue and can help you navigate before and during a health crisis. We are experts of this at My Doctor Medical Group in San Francisco, and it’s one of the reasons our patients go out of network to choose us for primary care.  After all, the costs of outpatient care are tiny compared to hospital care, and it’s often a worthwhile investment to have a doctor on your team who works for you, not your insurance company, when the chips are down.

The Daily Show with Jon Stewart (http://www NULL.thedailyshow NULL.com/watch/thu-february-21-2013/steven-brill)
Get More: Daily Show Full Episodes (http://www NULL.thedailyshow NULL.com/full-episodes/),Political Humor & Satire Blog (http://www NULL.indecisionforever NULL.com/),The Daily Show on Facebook (http://www NULL.facebook NULL.com/thedailyshow)

 

Celiac Pathology

How can I find out if I have celiac disease?

I often see patients who are concerned about gluten sensitivity or celiac disease. Indeed, that is a common problem and many people do feel better if they removed processed foods, and gluten in particular, from their diet.

The problem is that it matters how you go about investigating your body’s response to gluten.

What is celiac disease?

Celiac disease is an auto-immune response to gluten ingested in food. In other words, your own immune system attacks your body because it inappropriately reacts to gluten (contained in grains like wheat, rye and spelt) that you eat. Celiac disease can have all sorts of harmful effects on the body, ranging from diarrhea to anemia to nerve damage to increased rates of certain cancers.

Celiac Pathology

For more information on celiac disease, you can check out this article on UpToDate.com (http://www NULL.uptodate NULL.com/contents/celiac-disease-in-adults-beyond-the-basics).

How can celiac disease be best diagnosed? 

There is an important difference between gluten sensitivity and true celiac disease.  Gluten sensitivity is more common, and can potentially be improved or reversed by improving the overall health of the intestinal mucosa and immune system. Celiac disease, however, tends to be a life-long problem and requires very strict removal of all gluten from the diet, forever. The consequences of not removing gluten strictly, if you have true celiac disease, can be increased risk of heart disease, cancer, and other serious illnesses down the line.

So I strongly recommend that everyone get properly tested, by a standard reference lab, for celiac disease before they remove gluten from their diet.  If you do the tests after eliminating gluten, they often falsely come up normal, and you won’t know. Again, you must be consuming some amount of gluten to get an accurate test result.

If you just have gluten sensitivity (diagnosed by an elimination-rechallenge experiment), there’s hope that you can fix your intestinal permeability and no longer have to be perfect about gluten avoidance.  However, if you have true celiac disease based on these tests, you must eliminate all gluten, strictly, for the rest of your life.

It’s an important distinction.

What tests are most appropriate?

I usually recommend checking only a serum tissue transglutaminase IgA antibody (anti-tTG IgA) and a serum total immunoglobulin A (IgA) level. There are certain circumstances when other blood tests, and even endoscopic biopsies, are required, but most people can rely on these two simple tests.  However, if the total IgA level is low, one must get further consultation to figure out how best to get an accurate test result.

How much do these tests cost?

Typically you will spend around $80-120 for the lab tests themselves, depending on where you go. Insurance may cover them if you have them done at a standard reference laboratory, ordered by a medical doctor, and have symptoms that “medically justify” the tests.

What if I’ve already eliminated gluten?

You have two choices. Continue off gluten very strictly, forever (i.e. assume you have true celiac disease). Or, you can restart eating some gluten daily for 4-6 weeks and then do the blood tests.  It really can take that long to start making the antibodies again after you’ve eliminated gluten.

Where can I get these tests done?

Here in California, labs must be ordered by a licensed health care provider. So you’ll need to visit a doctor who’s willing to do this for you. Even better, one (like a doctor here at My Doctor Medical Group) who knows what things costs and who can get you fair and transparent pricing on the lab tests.  You can also order these tests online from out-of-state companies, often at somewhat higher cost, without seeing a doctor.

What if I’m not sure what to do?

By all means, see a doctor who knows about these things, who can help explain your options and make sure you figure things out correctly. Like us, if you can come see us in San Francisco.

Why the #QuantifiedSelf Movement Will Continue to Make Inroads in Medicine

Excerpt from an article on The Medtech Pulse blog:

“Many of the people who come to my office…have come because modern medicine has failed them in some way, or they have used up its power to help them and they know not what else to do.” —Rachel Naomi Remen, MD

A couple of weeks ago, at Stanford Medicine X, Paul Abramson MD used that quotation to kick off a presentation on how the Quantified Self movement is intersecting with medicine. Abramson, originally an electrical engineer by training, discovered he was more motivated by listening to people’s stories and trying to help them than doing research in engineering. He then enrolled in medical school, and eventually began practicing family medicine. Later on, he began to dabble in self tracking to find out why he had been experiencing recurrent headaches. He later used data garnered from the experiments to link the headaches to a sleep problem and had an epiphany: “Why can’t we do [something similar] for a lot of people?”

Among the biggest problems in medicine, as Abramson sees it, is a lack of patient empowerment and poor customer service. The Quantified Self movement can be harnessed to help address such problems, he explained. In many ways, what health trackers are doing is an extension of a long medical tradition. “Doctors have been prescribing headache logs for people with migraines and dietary logs [for a long time.]” While the Quantified self movement gives adherents new power to monitor their health, most people, however, have limited success with self tracking unless they are highly motivated, he acknowledged. To deal with that issue, Abramson has come up with a paradigm in his medical practice to put the patient in touch with a data-tracking coach as well as the doctor. “It is a team based approach but it is really based on this self-exploratory model.” The quant coach works with a patient as a peer to help motivate them and interpret their health data.

You may find the original article here: http://www.qmed.com/mpmn/medtechpulse/why-quantified-self-movement-will-continue-make-inroads-medicine (http://www NULL.qmed NULL.com/mpmn/medtechpulse/why-quantified-self-movement-will-continue-make-inroads-medicine)

And Dr. Abramson’s Quantified Doctor blog here (http://quantdoctor NULL.com)

 

Paul Abramson MD

Dr. Abramson’s Talk at Medicine X 2012 on Self Tracking in Medical Care

I gave a talk on implementing self tracking in my medical practice at the Medicine X 2012 Conference at Stanford on September 28, 2012. A bit of perspective on the health care system and its shortcomings provided an introduction to a new model of care involving a Quant Coach as an integral member of a medical team, with the patient at the center.

Slides are here on SlideShare:

Self Tracking in a Medical Context: The Quant Coach (http://www NULL.slideshare NULL.net/paulabramsonMD/self-tracking-in-a-medical-context-the-quant-coach) from Paul Abramson MD (http://www NULL.slideshare NULL.net/paulabramsonMD)

 

A direct link is here: Quantified Doctor Talk: Slides on SlideShare (http://www NULL.slideshare NULL.net/paulabramsonMD/self-tracking-in-a-medical-context-the-quant-coach)

You may visit Dr. Abramson’s “Quantified Doctor” blog here: The Quantified Doctor (http://quantdoctor NULL.com)

 

Vitamin D3

Are you taking vitamin D supplements? Some suggestions.

Many patients come to me on vitamin D supplements, and there have been a lot of opinion pieces for and against vitamin D supplementation lately. Without getting into the data too deeply, it seems likely that vitamin D3 supplemention is probably going to turn out to be beneficial up to a point, but that over-supplementing is probably harmful even before you get to frank vitamin D toxicity (which is rare).

Three simple suggestions:

Vitamin D3

  1. If you’ve got chronic medical conditions, talk to a doctor about vitamin D testing and dosing to avoid any unintended consequences;
  2. Take vitamin D3 supplements with the meal of the day that contains the most fat/oils.  It’s a fat-soluble vitamin and this will increase absorption;
  3. If you are an adult and taking more than 2000 I.U. of vitamin D3 per day, it’s important to have a 25-OH-vitamin D blood test checked to make sure you’re in a reasonable range (in my view, 30-60 ng/mL).  It takes up to 6 weeks for levels to equilibrate after a dose change.

Of course, if you have specific questions about your health, please talk to your doctor, or come see us as a patient in San Francisco.

 

Study: Statin use leads to fatigue

What has long been observed by physicians, statin-induced fatigue, is now being demonstrated in proper randomized controlled studies.

Researchers took 1016 adults with elevated LDL cholesterol, and gave them simvastatin, pravastatin or placebo. At 6 months, those taking the statin medications were more likely to be fatigued both at rest and with exertion.

It makes sense to only use statin medication in those patients where the medications are likely to provide a net benefit, such as those who have demonstrated cardiovascular or cerebrovascular disease or

Tired

diabetes. Routine use to treat elevated cholesterol in lower risk populations is a bad idea, despite extensive drug company marketing to the contrary.

In cases where it’s not clear what to do, sometimes more advanced testing can be helpful to stratify risk and make an education decision about statin use.

Reference:
Archives of Internal Medicine: http://archinte.jamanetwork.com/article.aspx?articleid=1183454 (http://archinte NULL.jamanetwork NULL.com/article NULL.aspx?articleid=1183454)